Ok, after trying A LOT of things and many different computers and chatting with Yoyo support I found a workaround.First of all, this seems to be an issue with Nvidia drivers in Windows 10. Among all the PCs I tested on, the only ones who gave me problems were NVidia on a Windows 10. The same PC running Windows 7, the game runs smooth. 6-year old PC, the game still runs smooth.So I figured that Game Maker Studio activates some mode on the GPU or uses another method for rendering or something.If you go to the Graphics tab, under Windows on Global Game Settings, you'll see a section named "Advanced". Check the "Alternate Synchronization Method", create an exe, restart your PC and without opening GM, test it if it runs well now.